Sheffield Wednesday manager Steve Bruce fears striker Lucas Joao could miss the rest of the season with a knee injury.
Joao has not featured since the win over Swansea on February 23 and has returned to his native Portugal to consult a specialist.
Fernando Forestieri is also sidelined with a hamstring problem while Gary Hooper is still short of match fitness following a long injury lay-off. Josh Onomah is ruled out on Saturday but Sam Winnall is in contention to start after coming on as a substitute in the last two games.
Blackburn manager Tony Mowbray will give late fitness tests to a number of players ahead of the trip to Hillsborough. Jack Rodwell has missed the last two games and Danny Graham is struggling with a hamstring injury, but both could make the squad.
Amari'i Bell is doubtful after limping off in the first half of the win over Wigan. Charlie Mulgrew may not be fit to return due to a hamstring injury and Darragh Lenihan remains sidelined.
Sheffield Wednesday have lost just one of their last 10 home league games against Blackburn (W5 D4 L1), a 1-2 loss in March 2015.
Blackburn are looking to complete a league double over Sheffield Wednesday for the first time since the 1994-95 season, when Rovers won the Premier League title.
In all competitions, Steve Bruce has won nine of his last 10 home games against Blackburn (D1) since losing 0-4 in December 2003 with Birmingham City.
No Championship team have conceded more away goals this than Blackburn Rovers (38, level with Hull and Wigan).
Sheffield Wednesday have lost just one of their last 15 league matches (W7 D7 L1) and are unbeaten in their last 10 in a row, conceding just four times in that run.
Since the start of the 2017-18 season, Charlie Mulgrew has scored 10 penalties in league football for Blackburn - in that time, only Luka Milivojevic and Billy Kee (15 each) have scored more penalty goals in the top four tiers of English football.
David Prutton predicts: 3-1 (18/1 with Sky Bet)