West Brom goalkeeper Alex Palmer will play for Oldham in Saturday's Sky Bet League Two clash with Cambridge after signing on a seven-day emergency loan.
Daniel Iversen's Denmark Under-21s call-up and Zeus de la Paz's hamstring injury left the Latics without a senior goalkeeper, necessitating Palmer's short-term switch.
Midfielder Jose Baxter is out for six to eight weeks with ankle ligament damage sustained in last Monday's FA Cup first-round win at Hampton and Richmond. Striker Sam Surridge should be in contention, after spending a month out with a hamstring injury.
Cambridge boss Joe Dunne is expected to make changes in a bid to avoid the slow start which saw his side exit the FA Cup at Guiseley. David Amoo, Ade Azeez and Paul Lewis came off the substitutes' bench in the second-half fightback, which fell short as United exited the FA Cup.
Azeez scored twice in Tuesday's Checkatrade Trophy win over Colchester and could come into the starting line-up after returning from concussion against Guiseley.Midfielder Reggie Lambe is on international duty with Bermuda and unavailable, while forward Barry Corr is a long-term absentee with an ankle injury.
Oldham are winless in four Football League games against Cambridge (D2 L2), a run stretching back to September 2000.
Cambridge have won just one of their 11 trips to Oldham in the Football League (D4 L6), a 3-1 victory in September 2000.
Oldham have won just one of their last nine League Two games (D4 L4), a 2-0 victory against Cheltenham in October.
Cambridge have won each of their last three league games without conceding a single goal - only twice have the U's won four consecutive Football League games without conceding, in the third tier in January 1991 and in the fourth tier in April 1977.
Of players to have scored at least three goals in League Two so far this season, Oldham's Sam Surridge (6 goals) has the best minutes to goal ratio (one goal every 93 minutes).