Santini spearheads Nicky Henderson's four-strong assault on Albert Bartlett Novices' Hurdle at the Cheltenham Festival on Friday.
The Grade Two-winning six-year-old is favourite for the Grade One and will be joined in the line-up by stablemates Ok Corral, who was supplemented for the race, Chef Des Obeaux and Mr Whipped.
Ok Corral's owner JP McManus also supplemented the Joseph O'Brien-trained Tower Bridge.
Other major fancies in a 20-runner field include the Henry de Bromhead-trained Chris's Dream, Poetic Rhythm (Fergal O'Brien) and Calett Mad (Nigel Twiston-Davies).
Ballyward will be ridden by Ruby Walsh, with Willie Mullins having also declared Fabulous Saga (Danny Mullins) and Real Steel (Paul Townend).